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Vera therapeutics - Elevating  Patient Voices - At its core, manga storytelling celebrates resilience, identity, community, hope, and personal agency — values that resonate deeply with people navigating complex life challenges, like those in our IgAN community. At Vera Therapeutics, we strive to elevate the voices of people affected by IgA nephropathy. We listen closely to patients and care partners because we believe that understanding the lived experience and building genuine connections within the community are key to improving outcomes. Vera therapeutics - Elevating  Patient Voices - At its core, manga storytelling celebrates resilience, identity, community, hope, and personal agency — values that resonate deeply with people navigating complex life challenges, like those in our IgAN community. At Vera Therapeutics, we strive to elevate the voices of people affected by IgA nephropathy. We listen closely to patients and care partners because we believe that understanding the lived experience and building genuine connections within the community are key to improving outcomes.
Learn about IgAN A kidney disease that begins in the immune system.
B Cell Activation - B cell activity is controlled by many proteins. Two of these proteins are called BAFF and APRIL. BAFF and APRIL attach to B cells and send signals to make B cells multiply and make more antibodies. B Cell Activation - B cell activity is controlled by many proteins. Two of these proteins are called BAFF and APRIL. BAFF and APRIL attach to B cells and send signals to make B cells multiply and make more antibodies.
Abnormal IgA Production - In patients with IgAN, B cells make high levels of an abnormal form of IgA called Gd-IgA1. Abnormal IgA Production - In patients with IgAN, B cells make high levels of an abnormal form of IgA called Gd-IgA1.
Autoantibodies Form - The immune system recognizes Gd-IgA1 as abnormal. In response, B cells produce autoantibodies that attach to Gd-IgA1. Autoantibodies Form - The immune system recognizes Gd-IgA1 as abnormal. In response, B cells produce autoantibodies that attach to Gd-IgA1.
Immune Complex Formation - These stick together to form immune complexes, which build up in the kidneys and cause permanent damage. Immune Complex Formation - These stick together to form immune complexes, which build up in the kidneys and cause permanent damage.
Kidney Damage - The ongoing damage caused by immune complexes leads to abnormal amounts of protein and blood appearing in the urine and eventually decreases the filtering of waste products from the body, causing kidney failure. Kidney Damage - The ongoing damage caused by immune complexes leads to abnormal amounts of protein and blood appearing in the urine and eventually decreases the filtering of waste products from the body, causing kidney failure.

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